3-(2-(Diethoxyphosphorylacetyl)hydrazino)-1-(2,4-dimethoxybenzyl)benzo[f]quinoxalin-2(1H)-one → 3-[(Diethoxyphosphoryl)methyl]benzo[f]-1,2,4-triazolo[4,3-a]quinoxalin-12(11H)-one

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Reaction Steps

A solution of 3-(2-diethoxyphosphorylacetyl)hydrazino-1-(2,4-dimethoxybenzyl)benzo[f]quinoxalin-2(1H)-one (1.1 g crude product) and glacial acetic acid (40 ml) was heated under reflux for 12 h. The mixture was evaporated to dryness. The residue was recrystallized from isopropanol to give 400 mg of the title compound m.p. 195°-197° C. 1H-NMR (DMSO-d6): δ 1.18 (t, 6H), 4.08 (quint, 4H), 4.35 (d, 2H), 7.68 (m, 2H), 7.90 (d, 1H), 8.08 (m, 1H), 8.35 (d, 1H), 8.82 (m, 1H), 12.25 (s, 1H).

Provenance & Evidence