Benzenepropanoic acid → HCID 178520444, compound

HRID 744030Notes

Reaction equation

HRID 744030 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:12]1[CH:16]=[C:15]([CH2:17][CH2:18][CH2:19][NH2:20])[N:14]=[CH:13]1>>[NH:12]1[CH:16]=[C:15]([CH2:17][CH2:18][CH2:19][NH:20][C:9](=[O:11])[CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 107Benzenepropanoic acidHCID 178510931HCID 178510931, compound

Product 1

HCID 178520444HCID 178520444, compound

Procedure

The preparation is carried out as in Example 1 with 10 mmol of 3-phenylpropanoic acid and 3-(1H-imidazol-4-yl)propanamine as the amine component. The title compound is purified by chromatography and recrystallized in the hydrogenmaleate form from ethyl acetate/acetonitrile.

Workup

  1. customThe title compound is purified by chromatography
  2. customrecrystallized in the hydrogenmaleate form from ethyl acetate/acetonitrile

Sources & evidence

ORD record
ord-5a6e8f7c5caf4bd29514b83eacce2c2b
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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