Triethylamine → HCID 178523290, compound

HRID 744033Notes

Reaction equation

HRID 744033 reaction equation
Cl.Cl.[NH:3]1[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][NH2:11])[N:5]=[CH:4]1.C(N(CC)CC)C.[CH2:19]([N:26]=[C:27]=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[CH2:19]([NH:26][C:27]([NH:11][CH2:10][CH2:9][CH2:8][C:6]1[N:5]=[CH:4][NH:3][CH:7]=1)=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 76639Benzyl isocyanateHCID 178478695HCID 178478695, compound

Product 1

HCID 178523290HCID 178523290, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5 mmol of 3-(1H-imidazol-4-yl)propanamine dihydrochloride and 10 mmol of triethylamine are mixed in 10 ml of acetonitrile and, after addition of 5 mmol of benzyl isocyanate, the whole mixture is brought to boiling for 1 h at reflux. After evaporation under vacuum, the title compound is taken up in a small amount of water and recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Workup

  1. temperatureat reflux
  2. customAfter evaporation under vacuum
  3. customrecrystallized in the hydrogenmaleate form from ethanol/diethyl ether

Sources & evidence

ORD record
ord-2667e60b0d6c4d5baf120c3f51608529
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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