Water → HCID 178522838, compound

HRID 744034Notes

Reaction equation

HRID 744034 reaction equation
Cl.[NH:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][OH:10])[N:4]=[CH:3]1.C([N:13]([CH2:16][CH3:17])[CH2:14]C)C.[OH2:18]>>[CH2:16]([NH:13][C:14](=[O:18])[O:10][CH2:9][CH2:8][CH2:7][C:5]1[N:4]=[CH:3][NH:2][CH:6]=1)[C:17]1[CH:9]=[CH:8][CH:7]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 178479684HCID 178479684, compound

Product 1

HCID 178522838HCID 178522838, compound

Procedure

The preparation is carried out as in Example 23 with 3-(1H-imidazol-4-yl)propanol hydrochloride and 5 mmol of triethylamine. The residual oil is taken up in a small amount of water. The title compound is crystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Workup

  1. customThe title compound is crystallized in the hydrogenmaleate form from ethanol/diethyl ether

Sources & evidence

ORD record
ord-7de495b13eab485b85ad36b4a007434c
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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