Potassium Carbonate → HCID 178527215, compound

HRID 744038Notes

Reaction equation

HRID 744038 reaction equation
C(=O)([O-])[O-].[K+].[K+].[NH:7]1[CH:11]=[C:10]([CH2:12][CH2:13][CH2:14][S:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:9]=[CH:8]1.ClC1C(C(OO)=[O:33])=CC=CC=1>ClCCl>[NH:7]1[CH:11]=[C:10]([CH2:12][CH2:13][CH2:14][S:15]([CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:33])[N:9]=[CH:8]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 125873982-Chlorobenzene-1-carboperoxoic acidHCID 1784202743-Phenylpropyl 3-(1H-imidazol-4-yl)propyl sulphide

Product 1

HCID 178527215HCID 178527215, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

0.5 g of potassium carbonate in 40 ml of dichloromethane are added to 2 mmol of the compound obtained in Example 46 and the mixture is stirred for 30 min. 2.5 mmol of chloroperbenzoic acid in 20 ml of dichloromethane are slowly added to the suspension and the mixture is stirred for 2 h at room temperature. The suspension is filtered and purification is carried out by chromatography. The title compound is recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.

Workup

  1. stirringthe mixture is stirred for 2 h at room temperature
  2. filtrationThe suspension is filtered
  3. custompurification
  4. customThe title compound is recrystallized in the hydrogenmaleate form from ethanol/diethyl ether

Sources & evidence

ORD record
ord-332037692e324bcabb53439d50a891ec
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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