Hydrogen Bromide → Dihydrobromide monohydrate

HRID 744058Notes

Reaction equation

HRID 744058 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1.[SH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.[BrH:16]>>[NH:7]1[CH:8]=[C:4]([CH2:3][CH2:2][S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[N:5]=[CH:6]1.[OH2:1].[BrH:16].[BrH:16]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 178418616HCID 178418616, compoundHCID 178520346HCID 178520346, compound

Product 2

HCID 21713259Dihydrobromide monohydrateHCID 178420566HCID 178420566, compound

Procedure

0.5 g (4.4 mmol) of 4-(2-hydroxyethyl)-1H-imidazole and 0.49 g (44.4 mmol) of 2-mercaptopyridine are brought to reflux in 5 ml of 47% aqueous HBr for 24 h. The solvent is removed azeotropically with isopropanol under reduced pressure to provide the title compound in the form of a dihydrobromide monohydrate salt which, after crystallization from isopropanol, melts at 189°-190° C.

Workup

  1. customThe solvent is removed azeotropically with isopropanol under reduced pressure

Sources & evidence

ORD record
ord-5867b7b0db854ebb95c4656d79b1c502
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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