4-Pyridinepropanol → HCID 19696542, compound

HRID 744114Notes

Reaction equation

HRID 744114 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1.[CH3:11][CH2:12][OH:13].CC(O)=O.O>[Pd]>[C:12]([O:10][CH2:9][CH2:8][CH2:7][CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1)(=[O:13])[CH3:11]

Participants

4

Reactant 2

HCID 729234-PyridinepropanolHCID 86584229Acetic acid ethanol water

Product 1

HCID 19696542HCID 19696542, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Commercially available 4-pyridinepropanol (6-10) (38 g, 277 mmol) was dissolved in 100 ml EtOH/HOAc/H2O (4:1:1) and treated with 2.0 g 10% Pd/C. This mixture was hydrogenated on a Parr reactor for 24 h at 55 psi. The catalyst was removed by filtration and the filtrate evaporated to give 3-(4-piperidinyl)propyl acetate.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-d9ba7946cc334b3fbcc21ae753eadec4
Source dataset
uspto-grants-1996_09
Patent number
US05559127

Reaction notes

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