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HRID744140

反应详情

EQUATION

反应方程式

HRID 744140 的结构方程式

REACTANTS

反应物

2
结构：CNS(=O)(=O)Cc1ccc(NC(=O)C(F)(F)F)c(Br)c1
HCID11003296

未命名化合物

结构：O=C(OCc1ccccc1)N1CCC[C@@H]1C=CCO
HCID54485243

(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene

C15H19NO3

PRODUCTS

生成物

1
结构：CNS(=O)(=O)Cc1ccc(N(CC=C[C@H]2CCCN2C(=O)OCc2ccccc2)C(=O)C(F)(F)F)c(Br)c1
HCID54094024

未命名化合物

收率 44%

PROCEDURE

实验过程

(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene and 2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline were used. Column chromatography using elution with 4% acetone in methylene chloride afforded the title compound as a white foam (44%): FAB LRMS (m/z, relative intensity) 620 ([MH+ with 81Br], 618 ([MH+ with 79Br], 98), 576 (50), 574 (63), 512 (17), 484 (33).

WORKUP

后处理

  1. washelution with 4% acetone in methylene chloride