2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline → (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-methylaminosulfonylmethylphenyl)-N-trifluoroacetylamino)propene

Participants

Role	Name	HCID	Charge
Reactant	2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline	HCID 11003296	—
Reactant	(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene	HCID 54485243	—
Product	(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-methylaminosulfonylmethylphenyl)-N-trifluoroacetylamino)propene	HCID 54094024	44%

Reaction Steps

(R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene and 2-bromo-4-methylaminosulfonylmethyl-N-trifluoroacetylaniline were used. Column chromatography using elution with 4% acetone in methylene chloride afforded the title compound as a white foam (44%): FAB LRMS (m/z, relative intensity) 620 ([MH+ with 81Br], 618 ([MH+ with 79Br], 98), 576 (50), 574 (63), 512 (17), 484 (33).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05559129
Source dataset	uspto-grants-1996_09
ORD ID	ord-b27f22571d244fa7afcfefb1481619a2
Source note	uspto-grants-1996_09