[6-[Tert-butylsilyloxy(diphenyl)methyl]-2-pyridinyl]methanol → 6-[Tert-butylsilyloxy(diphenyl)methyl]pyridine-2-carbaldehyde

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Reaction Steps

100 g of manganese dioxide is added in portions to a solution of 20 g of 6-(diphenyl-tert-butylsilyloxymethyl)-2-hydroxymethylpyridine in 236 ml of toluene at 24° C. under nitrogen and stirred for 24 hours. It is filtered on Celite, rewashed well with toluene and concentrated by evaporation in a vacuum. 19.0 g of the title compound is obtained as colored liquid, which is further used without further purification.

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