Methanol → 131987-61-6

HRID 744590Notes

Reaction equation

HRID 744590 reaction equation
[Na].Cl[C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1.[CH3:14][OH:15]>>[CH3:14][O:15][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

Product 1

HCID 15180130131987-61-6

Conditions

Temperature
50 °C

Procedure

To a solution of sodium (460 mg, 20 mmol) in methanol (10 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (750 mg, 3.8 mmol). The mixture was stirred at 50° C. for h and evaporated. The residue was dissolved in water and extracted with methylene chloride. The combined organic phases were dried and evaporated to give the title compound, which crystallized with petroleum ether in a 630 mg (86%) yield.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with methylene chloride
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-124b7fc888a34bb8832cadb956cc5a7e
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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