1-Butanol → HCID 15180173, compound

HRID 744676Notes

Reaction equation

HRID 744676 reaction equation
[Na].Cl[C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][O:6][N:7]=1.[CH2:14]([OH:18])[CH2:15][CH2:16][CH3:17]>>[CH2:14]([O:18][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][O:6][N:7]=1)[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 5360545SodiumHCID 15180172HCID 15180172, compound

Product 1

HCID 15180173HCID 15180173, compound

Conditions

Temperature
25 °C

Procedure

To a solution of sodium (150 mg, 6.5 mmol) in 1-butanol (5 ml) was added 3-(4-chloro-1,2,5-oxadiazol-3-yl)pyridine (350 mg, 1.9 mmol). The mixture was stirred at 25° C. for 2 h and evaporated. The residue was dissolved in water and extracted with ether. The combined organic phases were dried and evaporated to give the title compound.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ether
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-98c87d39cf464d1bbb535579bf127bcd
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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