Phosphorus pentachloride → HCID 178509736, compound

HRID 744712Notes

Reaction equation

HRID 744712 reaction equation
C([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)(O)[CH2:15][CH2:16][C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)=[CH:10][CH:9]=1)=O)(C)(C)C.P(Cl)(Cl)(Cl)(Cl)Cl>C(#N)C>[C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:28]=2)=[CH:15][CH2:16][C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)=[CH:10][CH:9]=1)#[N:5]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 178449309HCID 178449309, compound

Product 1

HCID 178509736HCID 178509736, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-[3-(4-tert-butylaminocarbonylphenyl)-3-(4-trifluoromethylphenyl)-3-hydroxypropyl]-1H-imidazole is refluxed with PCl5 (1,2 eqv) in dry acetonitrile to give the product. Yield 97%.

Workup

  1. customto give the product

Sources & evidence

ORD record
ord-20b78a0d28ea42649f1b88738739140a
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

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