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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 744712Generated: October 30, 2026

Phosphorus pentachloride → HCID 178509736, compound

https://huagongshe.com/reaction/744712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus pentachlorideHCID 24819—
ReactantHCID 178449309HCID 178449309—
SolventAcetonitrileHCID 6342—
ProductHCID 178509736HCID 17850973697%

Reaction Steps

4-[3-(4-tert-butylaminocarbonylphenyl)-3-(4-trifluoromethylphenyl)-3-hydroxypropyl]-1H-imidazole is refluxed with PCl5 (1,2 eqv) in dry acetonitrile to give the product. Yield 97%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05559141
Source datasetuspto-grants-1996_09
ORD IDord-20b78a0d28ea42649f1b88738739140a
Source noteuspto-grants-1996_09