HCID 19422028, compound → HCID 178509739, compound

HRID 744714Notes

Reaction equation

HRID 744714 reaction equation
Cl.C([N:9]1[CH:13]=[C:12]([CH2:14][CH:15]=[C:16]([C:25]2[CH:30]=[CH:29][C:28]([C:31]#[N:32])=[CH:27][CH:26]=2)[C:17]2[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=2)[N:11]=[CH:10]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:23]([C:20]1[CH:19]=[CH:18][C:17]([CH:16]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[N:32])=[CH:29][CH:30]=2)[CH2:15][CH2:14][C:12]2[N:11]=[CH:10][NH:9][CH:13]=2)=[CH:22][CH:21]=1)#[N:24]

Participants

5

Reactant 2

HCID 19422028HCID 19422028, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 178509739HCID 178509739, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1 eqv. of 1-benzyl-4-[3,3-bis(4-cyanophenyl)-2-propenyl]-1H-imidazole hydrochloride is dissolved in ethanol (40 ml) and a catalytic aamount of 10% Pd/C is added. The reaction mixture is stirred at 40° C. in a hydrogen atmosphere until the uptake of hydrogen ceases. The mixture is filtered and the filtrate is evaporated to dryness. The residue which is the product is purified by column chromatography methylene chloride-methanol (9:1) as eluent.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate is evaporated to dryness
  3. customis purified by column chromatography methylene chloride-methanol (9:1) as eluent

Sources & evidence

ORD record
ord-05ce49230507426394f819a4ae048905
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

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