HCID 19422046, compound → HCID 19422048, compound

HRID 744715Notes

Reaction equation

HRID 744715 reaction equation
[CH2:1]([N:8]1[C:12]([CH:13]([OH:23])[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClC(Cl)=C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([N:8]1[C:12]([C:13](=[O:23])[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 19422046HCID 19422046, compound

Product 1

HCID 19422048HCID 19422048, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 31373TetrachloroethyleneSolvent

Procedure

The mixture of 27,5 g of 1-benzyl-5-(1-hydroxy-4-phenylbutyl)-1H-imidazole and 34,4 g of manganese dioxide in 550 ml of tetrachloroethylene is refluxed stirring for four hours. The reaction mixture is filtered and the filtrate is evaporated to dryness. The product is crystallized from ethyl acetate as hydrochloride salt.

Workup

  1. temperatureis refluxed
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customThe product is crystallized from ethyl acetate as hydrochloride salt

Sources & evidence

ORD record
ord-748f8fe0c3bc4ab7b044672bbd60e757
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

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