反应详情

12,95 g of 1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1-H-imidazole is dissolved into ethanol (400 ml) and water (130 ml). 8,17 g of ammonium formate and 1,3 g of 10% Pd/C is added to the solution and the mixture is refluxed for three hours. Then the reaction mixture is filtered through siliceous earth and the flitrate is evaporated to dryness. The residue is dissolved into ethyl acetate, washed with 2M aqueous sodium hydroxide and water, dried and evaporated to dryness.

1. temperaturethe mixture is refluxed for three hours
2. filtrationThen the reaction mixture is filtered through siliceous earth
3. customthe flitrate is evaporated to dryness
4. dissolutionThe residue is dissolved into ethyl acetate
5. washwashed with 2M aqueous sodium hydroxide and water
6. customdried
7. customevaporated to dryness