Water → HCID 178509743, compound

HRID 744720Notes

Reaction equation

HRID 744720 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:25]2[N:26]=[CH:27][NH:28][CH:29]=2)[C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20]C(C)(C)C)=O)=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)Cl.O>C(#N)C>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([CH:11]([C:25]2[N:26]=[CH:27][NH:28][CH:29]=2)[CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:13][CH:14]=1)#[N:20]

Participants

5

Reactant 3

HCID 962WaterHCID 24819Phosphorus pentachlorideHCID 178449296HCID 178449296, compound

Product 1

HCID 178509743HCID 178509743, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

4-[4-(4-fluorophenyl)-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole (7 g) is dissolved into dry acetonitrile (200 ml). 3,6 g of phosphorus pentachloride is added and the mixture is poured into water and acetonitrile is evaporated. The water solution is rendered alkaline and extracted with ethyl acetate. The ethyl acetate phase is washed with water, dried and evaporated to dryness. Yield 85%.

Workup

  1. customis evaporated
  2. extractionextracted with ethyl acetate
  3. washThe ethyl acetate phase is washed with water
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-fa3307e2c52645b5ab998b1f9251ab4b
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

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