Water → HCID 178509743, compound

Participants

Reaction Steps

4-[4-(4-fluorophenyl)-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole (7 g) is dissolved into dry acetonitrile (200 ml). 3,6 g of phosphorus pentachloride is added and the mixture is poured into water and acetonitrile is evaporated. The water solution is rendered alkaline and extracted with ethyl acetate. The ethyl acetate phase is washed with water, dried and evaporated to dryness. Yield 85%.

Provenance & Evidence