1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole → 1-benzyl-5-[4-(4-fluorophenyl)-1-oxobutyl]-1H-imidazole

HRID 744722Notes

Reaction equation

HRID 744722 reaction equation
[CH2:1]([N:8]1[C:12]([CH:13]([OH:24])[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClC(Cl)=C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([N:8]1[C:12]([C:13](=[O:24])[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 194219941-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole

Product 1

HCID 194219891-benzyl-5-[4-(4-fluorophenyl)-1-oxobutyl]-1H-imidazole

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 31373TetrachloroethyleneSolvent

Procedure

The mixture of 36,1 g of 1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole and 53 g manganese dioxide in 550 ml of tetrachloroethylene is refluxed stirring for four hours. The reaction mixture is filtered through siliceous earth and the flitrate is evaporated to dryness. The product is crystallized from acetone as hydrochloride salt.

Workup

  1. temperatureis refluxed
  2. filtrationThe reaction mixture is filtered through siliceous earth
  3. customthe flitrate is evaporated to dryness
  4. customThe product is crystallized from acetone as hydrochloride salt

Sources & evidence

ORD record
ord-1eaf8d64c5354e2ea70a92fe24b197f2
Source dataset
uspto-grants-1996_09
Patent number
US05559141

Reaction notes

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