HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole → 1-benzyl-5-[4-(4-fluorophenyl)-1-oxobutyl]-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole | HCID 19421994 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Tetrachloroethylene | HCID 31373 | — |
| Product | 1-benzyl-5-[4-(4-fluorophenyl)-1-oxobutyl]-1H-imidazole | HCID 19421989 | — |
Reaction Steps
The mixture of 36,1 g of 1-benzyl-5-(4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole and 53 g manganese dioxide in 550 ml of tetrachloroethylene is refluxed stirring for four hours. The reaction mixture is filtered through siliceous earth and the flitrate is evaporated to dryness. The product is crystallized from acetone as hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05559141 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-1eaf8d64c5354e2ea70a92fe24b197f2 |
| Source note | uspto-grants-1996_09 |