反应详情

1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole hydrochloride (12,95 g) is dissolved into aqueous ethanol (400 ml) and 1,3 g of 10% Pd/C is added. Ammonium formate (8,17 g) is added to the boiling solution in small portions. The mixture is refluxed for three hours. Then the reaction mixture is filtered through siliceous earth and the filtrate is evaporated to dryness. The residue is dissolved to methylene chloride, washed with 2M sodiumhydroxide and water, dried and evaporated to dryness. Yield 79%.

1. additionis added
2. temperatureThe mixture is refluxed for three hours
3. filtrationThen the reaction mixture is filtered through siliceous earth
4. customthe filtrate is evaporated to dryness
5. dissolutionThe residue is dissolved to methylene chloride
6. washwashed with 2M sodiumhydroxide and water
7. customdried
8. customevaporated to dryness