HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → HCID 19422003, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | Ethyl 4-formylbenzoate | HCID 80498 | — |
| Reactant | 1-(1-Benzyl-1H-imidazol-5-yl)ethan-1-one | HCID 11615368 | — |
| Reactant | HCID 54337796 | HCID 54337796 | — |
| Product | HCID 19422003 | HCID 19422003 | — |
Reaction Steps
1-benzyl-5-[3-(4-tert-butylaminocarbonylaminophenyl)-1-(4-fluorophenyl)1-hydroxypropyl]-1H-imidazole is prepared from 1 -benzyl-5-[3-(4-tert-butylaminocarbonylphenyl)-1-oxopropyl]-1H-imidazole (synthesized by aldol condensation from 1-benzyl-5-acetyl-1H-imidazole and 4-ethoxycarbonylbenzaldehyde followed by hydrogenation, converting to corresponding acid chloride and allowing the product to react with tert-butylamine) and 4-bromofluorobenzene by the method described in the example 7c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05559141 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-15271cc6b28e43129705559cde0e4358 |
| Source note | uspto-grants-1996_09 |