反应详情

1-benzyl-5-[3-(4-tert-butylaminocarbonylaminophenyl)-1-(4-fluorophenyl)1-hydroxypropyl]-1H-imidazole is prepared from 1 -benzyl-5-[3-(4-tert-butylaminocarbonylphenyl)-1-oxopropyl]-1H-imidazole (synthesized by aldol condensation from 1-benzyl-5-acetyl-1H-imidazole and 4-ethoxycarbonylbenzaldehyde followed by hydrogenation, converting to corresponding acid chloride and allowing the product to react with tert-butylamine) and 4-bromofluorobenzene by the method described in the example 7c).