反应详情

温度

0 °C

To a solution of 2.3 g of 2(R)-isopropyl-3-(p-tert-butyl-phenyl)-propanol in 50 ml of dichloromethane there are added, with stirring at 0° C., 3.15 g of triphenylphosphine and then, in portions, 2.14 g of N-bromosuccinimide. The reaction mixture is subsequently stirred for 16 hours at room temperature and is then concentrated by evaporation. The residue is purified by FC (100 g of silica gel, eluant; dichloromethane/hexane=1:1). The title compound is obtained: Rf (hexane)=0.49.

1. stirringThe reaction mixture is subsequently stirred for 16 hours at room temperature
2. concentrationis then concentrated by evaporation
3. customThe residue is purified by FC (100 g of silica gel, eluant; dichloromethane/hexane=1:1)