Hydrochloric Acid → HCID 57480420, compound

HRID 744830Notes

Reaction equation

HRID 744830 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6](=[O:21])[CH2:7][CH2:8][CH2:9][NH:10]C(OCC1C=CC=CC=1)=O.[ClH:22]>CO.[Pd]>[ClH:22].[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6](=[O:21])[CH2:7][CH2:8][CH2:9][NH2:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54038932HCID 54038932, compound

Product 1

HCID 57480420HCID 57480420, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.95 g of 4-benzyloxycarbonylaminobutyric acid N-(2-methoxyethyl)amide are hydrogenated in the presence of 0.24 g of 10% Pd/C in 150 ml of methanol and 100 ml of 0.1N hydrochloric acid for 2 hours at room temperature and under normal pressure. The reaction mixture is filtered and concentrated by evaporation. The crude title compound is obtained: 1H NMR (CD3OD), δ(ppm)=4.92(4H, s), 3.53-3.20 (4H, m), 3.34 (3H, 2.96 (2H, t, J=12 Hz), 2.37 (2H, t, J=12 Hz), 1.93 (2H, m).

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-57e425d333934c1eb040e5693e1aecd0
Source dataset
uspto-grants-1996_09
Patent number
US05559111

Reaction notes

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