反应详情

20 g of ethyl 1-cyanocyclopentanecarboxylate are placed in 200 ml of a 10% solution of ammonia in ethanol and hydrogenated at 60° C. under a pressure of 100 bar in the presence of rhodium-on-alumina for 72 hours. After filtration on cellite® -- and evaporation, the residue is chromatographed on silica using a DCM/methanol/20% aqueous ammonia mixture (98/2/0.5; v/v/v) as the eluent.

1. filtrationAfter filtration on cellite®
2. customevaporation
3. customthe residue is chromatographed on silica using a DCM/methanol/20% aqueous ammonia mixture (98/2/0.5