反应详情

N-[4-(4-cyclohexylaminopiperidino)-2-(3,4-dichlorophenyl)-butyl]-N-methylbenzamide was dissolved in dichloromethane (4.0 mL), and triethylamine (1.0 mL) and acetic anhydride (0.65 mL) were added. After being stirred for 2 hours, the mixture was washed with aqueous sodium bicarbonate, dried, and evaporated. The resulting material was chromatographed, with dichloromethane:methanol (95:5) as the eluent, to give the title compound (0.60 g) as a white solid; MS: m/z=558(M+1). Analysis for C31H41Cl2N3O2 ·0.6 CH2Cl2 : Calculated: C, 62.26; H, 6.98; N, 6.89. Found: C, 62.15; H, 6.99; N, 7.30

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4. customThe resulting material was chromatographed, with dichloromethane:methanol (95:5) as the eluent