反应详情

温度

100 °C

35.0 g (216 mmol) N,N′-carbonyldiimidazole were added to 23.9 g (70.3 mmol) [2-(2-amino-5-methoxyphenyl)-ethyl]-(1-benzylpiperidin-4-yl)-amine in 175 mL DMF and the mixture was stirred for 2 h at 100° C. The reaction mixture was poured onto approx. 1 kg ice water and stirred overnight. The precipitated product was suction filtered, washed with 100 mL water and dried. The residue was stirred with 150 mL DIPE and suction filtered. The solid product was washed with 50 mL DIPE and dried.

1. stirringstirred overnight
2. filtrationfiltered
3. washwashed with 100 mL water
4. customdried
5. stirringThe residue was stirred with 150 mL DIPE and suction
6. filtrationfiltered
7. washThe solid product was washed with 50 mL DIPE
8. customdried