反应详情

63.5 g (0.29 mol) sodium diethyloxalacetate and 30.2 g (0.29 mol) formamidine acetate were added to 24.1 g (0.6 mol) NaOH in 3.6 L water. The mixture was stirred overnight at RT. Then activated charcoal was added and the mixture was refluxed for 1 h. It was filtered off hot and after cooling acidified with aqueous hydrochloric acid. The solution was evaporated to dryness by rotary evaporation. The residue contained the desired product and was used in the next step without any further purification.

1. temperaturethe mixture was refluxed for 1 h
2. filtrationIt was filtered off hot
3. temperatureafter cooling
4. customThe solution was evaporated to dryness by rotary evaporation
5. customwas used in the next step without any further purification