反应详情

温度

80 °C

Phenyl chloroformate (0.80 g, 5.1 mmol) and 3-phenyl-propionaldehyde (0.96 g, 7.2 mmol) were dissolved in 1,2-dichloroethane (5 ml) and pyridine (0.020 g, 0.25 mmol) was added dropwise to the stirred solution. Stirred at 80° C. for 2 days. Washed with water (10 ml), dried (MgSO4) and concentrated. Purified by flash chromatography (Silikagel 60, petroleum ether/ethyl acetate 95:5). Yield: 0.45 g 1H-NMR (CDCl3): delta=2.43 (CH2CH); 2.87 (CH2CH2CH); 6.34 (CH); 7.19-7.41 ppm (phenyl).

1. washWashed with water (10 ml)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. customPurified by flash chromatography (Silikagel 60, petroleum ether/ethyl acetate 95:5)