反应详情

To a solution of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (0.5 g) in dichloromethane (20 ml) is added triethylamine (0.3 g), and thereto is added benzoyl chloride (0.28 g) under ice-cooling. The mixture is stirred at room temperature for 1 hour. To the reaction mixture is added water and extracted with dichloromethane. The extract is dried over magnesium sulfate and the solvent is distilled off under reduced pressure. The resulting residue is purified by silica gel column chromatography (eluent; dichloromethane:methanol=50:1) and recrystallized from methanol to give 1-[4-(benzoylamino)benzoyl]-1,2,3,4-tetrahydroquinoline (245 mg) as white powder, m.p. 202.5°-203.5° C.

1. temperaturecooling
2. extractionextracted with dichloromethane
3. dry with materialThe extract is dried over magnesium sulfate
4. distillationthe solvent is distilled off under reduced pressure
5. customThe resulting residue is purified by silica gel column chromatography (eluent; dichloromethane:methanol=50:1)
6. customrecrystallized from methanol