Ethyl formate → HCID 19608166, compound

HRID 745099Notes

Reaction equation

HRID 745099 reaction equation
[NH2:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:13](=[O:30])[C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:29])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[CH3:28])=[CH:16][CH:15]=2)[CH2:5][CH2:4][CH2:3]1.[CH:31](OCC)=[O:32]>>[CH:31]([NH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:13](=[O:30])[C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:29])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[CH3:28])=[CH:16][CH:15]=2)[CH2:5][CH2:4][CH2:3]1)=[O:32]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 10692311HCID 10692311, compound

Product 1

HCID 19608166HCID 19608166, compound

Procedure

A mixture of 5-amino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine (0.6 g) and ethyl formate (10 ml) is refluxed for 4 hours. The reaction solution is concentrated and the resulting residue is recrystallized from ethanol/petroleum ether to give 5-formylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine (0.38 g) as colorless columnar crystal, m.p. 211°-213° C.

Workup

  1. temperatureis refluxed for 4 hours
  2. concentrationThe reaction solution is concentrated
  3. customthe resulting residue is recrystallized from ethanol/petroleum ether

Sources & evidence

ORD record
ord-1f91582545394dee97bf1f86bb1b490d
Source dataset
uspto-grants-1996_09
Patent number
US05559230

Reaction notes

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