HCID 6915783, compound → HCID 74972732, compound

HRID 745122Notes

Reaction equation

HRID 745122 reaction equation
[CH3:1][C:2]([CH3:46])([O:4][C:5]([NH:7][CH:8]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH:9]([OH:38])[CH2:10][N:11](CC1C=CC=CC=1)[CH2:12][CH:13]([OH:30])[CH:14]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:6])[CH3:3]>CO>[NH:11]([CH2:10][CH:9]([OH:38])[CH:8]([NH:7][C:5](=[O:6])[O:4][C:2]([CH3:46])([CH3:3])[CH3:1])[CH2:39][CH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1)[CH2:12][CH:13]([OH:30])[CH:14]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:26])[CH3:27])[CH2:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 1

HCID 6915783HCID 6915783, compound

Product 1

HCID 74972732HCID 74972732, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Starting from N-Boc-L-cyclohexylalanine in place of N-Boc-L-phenylalanine, the title Compound 14 (white solid) was prepared using procedures analogous to those described for Compounds 1b(i), 4b, and 7. [α]D =-33.7° (c 0.18, MeOH). 13C NMR (CDCl3): δ26.1, 26.4, 26.5, 28.4, 32.3, 34.2, 34.3, 38.1, 51.0, 51.6, 72.7, 79.5, 156.4. Mass Spec. (M+H )+ @556. High Resolution FAB; exact mass calcd. for C30H58O6N3 (M+H)+, 556,4325; Found 556.4304.

Sources & evidence

ORD record
ord-5388cdd8c0114a6fa9ee419933e9a8b4
Source dataset
uspto-grants-1996_09
Patent number
US05559256

Reaction notes

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