反应详情

温度

65 °C

Under a nitrogen atmosphere 0.60 mL (0.60 mmol) of a 1M solution of lithium aluminium hydride in THF was added dropwise to 100 mg (0.58 mmol) spiro[cyclobutan-1,3′-indolin]-2′-one in 20 mL THF. Then the reaction mixture was stirred for 1 h at 65° C. After cooling 1 mL water was added and the mixture was stirred for 10 min. The organic phase was dried on sodium sulphate and evaporated down. The product was reacted without further purification.

1. additionwas added
2. stirringthe mixture was stirred for 10 min
3. customThe organic phase was dried on sodium sulphate
4. customevaporated down
5. customThe product was reacted without further purification