反应详情

A mixture of 1-(2-pyrimidinyl)piperazine (2 g; 12.2 mmol), acetone (2 ml), 1-bromo-3-chloropropane (2.5 g; 15.9 mmol) and a 25% aqueous sodium hydroxide solution (1.9 ml) was stirred at room temperature for 6 hours. After completion of the reaction, the resultant mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 1-(3-chloropropyl)-4-(2-pyrimidinyl)piperazine. IR νmaxFilm (cm-1): 1595, 1550, 1500.

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with a saturated sodium chloride solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed under reduced pressure