HCID 13120655, compound → HCID 13120656, compound

HRID 745223Notes

Reaction equation

HRID 745223 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12](=[O:17])[NH:13][CH2:14][CH2:15][N:16]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.[Ni]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[NH:16][CH2:15][CH2:14][NH:13][C:12]2=[O:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 1

HCID 13120655HCID 13120655, compound

Product 1

HCID 13120656HCID 13120656, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

23.4 g (0.1 mol) of 3-(3,4-dimethoxyphenyl)-5,6-dihydro-2(1H)-pyrazinone are dissolved in 230 ml of ethanol and hydrogenated, in the presence of Raney nickel as the catalyst, at 40° to 60° C. and under a hydrogen pressure of 50 bar until saturation is reached. The catalyst is then filtered off, the filtrate is evaporated in vacuo and the residue is triturated with ether.

Workup

  1. customat 40° to 60° C.
  2. filtrationThe catalyst is then filtered off
  3. customthe filtrate is evaporated in vacuo
  4. customthe residue is triturated with ether

Sources & evidence

ORD record
ord-ed992ccd2bde438ca15c2b25aa07d8cf
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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