反应详情

温度

15 °C

At 15° C. 508 mg (8.10 mmol) sodium cyanoborohydride was added to 600 mg (2.63 mmol) 3-(3-pyrrolidin-1-yl-propyl)-1H-indole in 7.50 g acetic acid and the mixture was stirred for 1 h at 15° C. After this time another 600 mg sodium cyanoborohydride were added and the mixture was stirred at 15° C. for 3 h. The reaction mixture was evaporated down using the rotary evaporator and combined with 40 mL of a 4M hydrochloric acid solution. The reaction mixture was stirred for 1h at RT. Then the mixture was made basic with potassium carbonate and extracted with ethyl acetate (2×50 mL). The combined organic phases were dried and evaporated down i. vac. The product was reacted further without any further purification.

1. customAt 15° C
2. stirringthe mixture was stirred at 15° C. for 3 h
3. customThe reaction mixture was evaporated down
4. customthe rotary evaporator
5. stirringThe reaction mixture was stirred for 1h at RT
6. extractionextracted with ethyl acetate (2×50 mL)
7. customThe combined organic phases were dried
8. customevaporated down i
9. customThe product was reacted further without any further purification