Chloroacetyl chloride → HCID 23315297, compound

HRID 745231Notes

Reaction equation

HRID 745231 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[NH:11][CH2:10][CH2:9][NH:8][C:7]1=[O:12].C(N(CC)CC)C.[Cl:20][CH2:21][C:22](Cl)=[O:23]>C(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[N:11]([C:22](=[O:23])[CH2:21][Cl:20])[CH2:10][CH2:9][NH:8][C:7]1=[O:12]

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 65649Piperazinone, 3-(2-thienyl)- (9CI)

Product 1

HCID 23315297HCID 23315297, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

18.2 g (0.1 mol) of 3-(2-thienyl)-piperazin-2-one, prepared in accordance with Example 16, are dissolved in 150 ml of chloroform and 11.1 g (0.11 mol) of triethylamine and 12.4 g (0.11 mol) of chloroacetyl chloride are added. The mixture is stirred for 4 hours at room temperature, the reaction solution is concentrated in vacuo and the residue is stirred with water and ethyl acetate. The ethyl acetate solution is separated off, dried and evaporated in vacuo.

Workup

  1. concentrationthe reaction solution is concentrated in vacuo
  2. stirringthe residue is stirred with water and ethyl acetate
  3. customThe ethyl acetate solution is separated off
  4. customdried
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-10be8f4168ba4886a41395a30c2483ab
Source dataset
uspto-grants-1986_07
Patent number
US04598079

Reaction notes

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