Methyl formate → 1-Piperazinecarboxaldehyde, 2-(1H-indol-3-yl)-3-oxo-

HRID 745237Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[NH:15][CH2:14][CH2:13][NH:12][C:11]2=[O:16])=[CH:2]1.[CH3:17][O:18]C=O>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[N:15]([CH:17]=[O:18])[CH2:14][CH2:13][NH:12][C:11]2=[O:16])=[CH:2]1

Participants

Reactant 2

HCID 7865Methyl formate

HCID 131206953-(1H-Indol-3-yl)-2-piperazinone

Product 1

HCID 30700241-Piperazinecarboxaldehyde, 2-(1H-indol-3-yl)-3-oxo-

Procedure

21.5 g (0.1 mol) of 3-(3-indolyl)-piperazin-2-one (Example 30) are formylated with methylformate, as described in Example 5.

Sources & evidence

ORD record: ord-b21fb15113c84d0bac1464c888437a17
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04598079

Reaction notes

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