反应详情

At 0° C. 5 mL trifluoroacetic acid was added to 1.60 g (6.05 mmol) tert-butyl 7,7-dimethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylate (synthesised analogously to WO2005/065779) in 15 mL dichloromethane and the reaction mixture was stirred for 2 h at RT. Then the solvent was eliminated i. vac. The residue was combined with ethanol and evaporated down again i. vac. The residue was dissolved in ethanol and 12 mL of a 1.25 M ethanolic HCl solution were added. The mixture was again evaporated down i. vac. The residue was triturated with ethanol. The solid was suction filtered and dried.

1. customAt 0° C
2. customevaporated down again i
3. dissolutionThe residue was dissolved in ethanol
4. addition12 mL of a 1.25 M ethanolic HCl solution were added
5. customThe mixture was again evaporated down i
6. customThe residue was triturated with ethanol
7. filtrationfiltered
8. customdried