Hydrochloric Acid → HCID 23315204, compound

HRID 745246Notes

Reaction equation

HRID 745246 reaction equation
Cl.C([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([Cl:14])[CH:8]=1)(=O)C>C(O)C>[ClH:14].[NH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([Cl:14])[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13655324HCID 13655324, compound

Product 1

HCID 23315204HCID 23315204, compoundYield 198.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 80 ml of concentrated hydrochloric acid and 8 ml of ethanol, was added 8.0 g of 4-acetamidomethyl-2-chlorotoluene. The stirred mixture was heated overnight under reflux. The solvent was removed by distillation and the residue was washed out with acetone to yield 7.7 g of 4-aminomethyl-2-chlorotoluene hydrochloride; m.p. ≤242° C.

Workup

  1. temperatureThe stirred mixture was heated overnight
  2. temperatureunder reflux
  3. customThe solvent was removed by distillation
  4. washthe residue was washed out with acetone

Sources & evidence

ORD record
ord-5d974fb1a14a4e45a0306e67e3ff00d8
Source dataset
uspto-grants-1986_07
Patent number
US04598077

Reaction notes

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