反应详情

To 10 ml of p-tolualdehyde, were added 180 ml of ethanol, 9.8 g of malonic acid, and 15.8 g of ammonium acetate. The mixture was refluxed for 5 hours. After cooling, the insolubles were removed by filtration. After addition of 100 ml of water, the filtrate was adjusted to pH 7.0 with 1N hydrochloric acid, and the precipitated crystals were collected by filtration to yield 5.4 g of β-amino-β-(4-methylphenyl)propionic acid; m.p. 228°-229° C.

1. temperatureThe mixture was refluxed for 5 hours
2. temperatureAfter cooling
3. customthe insolubles were removed by filtration
4. additionAfter addition of 100 ml of water
5. filtrationthe precipitated crystals were collected by filtration