反应详情

To a mixture of 25 ml of chloroform and 50 ml of anhydrous methanol saturated with anhydrous hydrogen chloride while cooling in ice, was added 4.8 g of 3-methoxy-4-(4 -phthalimidomethylbenzyloxy)benzonitrile. The mixture was stirred at room temperature for 24 hours, then concentrated, and admixed with ethyl acetate to yield 3.4 g of colorless or pink solid methyl 3-methoxy-4-(4-phthalimidomethylbenzyloxy)benzimidate hydrochloride; m.p. 221°-222° C.

1. temperaturewhile cooling in ice
2. concentrationconcentrated