反应详情

1.04 g (5.50 mmol) benzyl-(2,2,2-trifluorethyl)-amine and 5.50 mL (5.50 mmol) of a 1M sodium hydroxide solution were added dropwise while cooling with a bath of ice/ethanol to 1.00 g (5.65 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 20 mL dichloromethane. The mixture was first stirred for 2 h while being cooled and then for a further 1 h at RT. 50 mL of a saturated sodium hydrogen carbonate solution were added and the mixture was stirred for 10 min. The organic phase was separated off, washed with water (1×30 mL) and 1M hydrochloric acid (1×50 mL), dried on sodium sulphate, filtered and evaporated down i. vac. The product was reacted further without any further purification.

1. temperaturewhile being cooled
2. waitfor a further 1 h at RT
3. stirringthe mixture was stirred for 10 min
4. customThe organic phase was separated off
5. washwashed with water (1×30 mL) and 1M hydrochloric acid (1×50 mL)
6. customdried on sodium sulphate
7. filtrationfiltered
8. customevaporated down i
9. customThe product was reacted further without any further purification