HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Carbonate → HCID 908572, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Carbonate | HCID 7766 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide | HCID 70469725 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 908572 | HCID 908572 | — |
Reaction Steps
A solution of 6,7-dimethoxy-1-carbamoylmethylene-1,2,3,4-tetrahydroisoquinoline (5.0 g) and an excess of sodium ethoxide (prepared from 12.0 g of sodium metal and 600 ml of ethanol) in ethanol is heated. 150.0 ml of diethyl carbonate is added to the solution. The reaction mixture is refluxed for an additional 2.5 hr. The solvent is removed under vacuum and the residue is acidified to give a white precipitate, yield 4.80 g. The product crystallizes from dimethylformamide, mp. 323°-325° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04598148 |
| Source dataset | uspto-grants-1986_07 |
| ORD ID | ord-f4de5f0e38ed4bb1a6e1f1894e99435c |
| Source note | uspto-grants-1986_07 |