反应详情

A solution of 6,7-dimethoxy-1-carbamoylmethylene-1,2,3,4-tetrahydroisoquinoline (5.0 g) and an excess of sodium ethoxide (prepared from 12.0 g of sodium metal and 600 ml of ethanol) in ethanol is heated. 150.0 ml of diethyl carbonate is added to the solution. The reaction mixture is refluxed for an additional 2.5 hr. The solvent is removed under vacuum and the residue is acidified to give a white precipitate, yield 4.80 g. The product crystallizes from dimethylformamide, mp. 323°-325° C.

1. temperatureThe reaction mixture is refluxed for an additional 2.5 hr
2. customThe solvent is removed under vacuum
3. customto give a white precipitate, yield 4.80 g
4. customThe product crystallizes from dimethylformamide, mp. 323°-325° C.