HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 3-ethylidene-1H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-ethylidene-1H-indol-2-one | HCID 53425662 | — |
Reaction Steps
0.85 mL (15 mmol) acetaldehyde were added dropwise to 2.0 g (15 mmol) indolin-2-one and 0.20 mL piperidine in 20 mL methanol. The reaction mixture was refluxed for 3 h and then evaporated down. The residue was triturated in diisopropylether and suction filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4f5a8908f17643f28c7d53c5f12ff7b8 |
| Source note | uspto-grants-2014_09 |