反应详情

2.0 g (15 mmol) 1,3-dihydro-indol-2-one and 0.20 mL piperidine were placed in 20 mL methanol. 1.1 mL (15 mmol) cyclopropanecarboxaldehyde were added dropwise, the reaction mixture was refluxed for 3 h and then concentrated to dryness by rotary evaporation. The residue was triturated with diisopropylether and the solid remaining was suction filtered and dried.

1. temperaturethe reaction mixture was refluxed for 3 h
2. concentrationconcentrated to dryness by rotary evaporation
3. customThe residue was triturated with diisopropylether
4. filtrationfiltered
5. customdried