Formaldehyde → Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

HRID 74536Notes

Reaction equation

HRID 74536 reaction equation
[CH3:1][C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)([CH3:5])[CH2:3][NH2:4].[CH2:11]=O>>[CH2:11]=[N:4][CH2:3][C:2]([CH3:5])([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH3:1]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 667224312-Methyl-2-(thien-3-yl)propylamine

Product 1

HCID 58117475Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

Procedure

5.75 g (37.0 mmol) 2-methyl-2-thiophene-3-yl-propylamine and 3.61 mL (44.4 mmol) formaldehyde were stirred overnight at RT together with 2.0 g molecular sieve (4 Å powder). The reaction mixture was filtered and the filtrate was concentrated to dryness by rotary evaporation.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-51e055cce98b4aae868fcb60b4fa2906
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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